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Reported a large no. of babies with kernicterus which seems to occur peculiarly in North India. Presented data to show that the risk of kernicterus in in outborn babies is significantly high at bilirubin > 20 mg/dl even in absence of hemolysis. .Also showed that SGA babies are at a much greater risk for kernicterus. It was also shown that urinary iodine excretion was significantly lower in babies with higher levels of bilirubin or persistently elevated bilirubin suggesting relationship be
Phenobarbitone was shown to be a cheap and effective modality for managing jaundice in babies < 1500 gms in a randomized controlled trial . .In another trial, it was demonstrated that majority of neonates reporting with high bilirubin had increased serum osmolality and intravenous fluid supplementation could reduce the need for exchange transfusion in these babies
It was shown that donor blood G6PD deficiency can prolong the need for phototherapy and increase the need for repeat exchange transfusions –hence it is recommended to screen the donor blood for G6 PD deficiency in neonates undergoing exchange transfusion
Neonatal infectionsEvaluated the role of routine lumbar puncture in neonatal sepsis and showed that the yield was virtually zero in absence of symptoms. Subsequently the practice was changed to doing lumbar puncture only in presence of symptoms
Demonstrated the significant role of fungi in neonatal infections beyond 7 days of life even in India. Efficacy of Fluconazole as a first line therapy and its effectiveness as a prophylactic agent in decreasing fungal infections was shown
AsphyxiaDemonstrated that the use of NaHCO3 in neonatal resuscitation did not improve any of the outcomes. Subsequently the practice of using NaHCO3 in labor room was discontinued
Prophylactic phenobarbitone was evaluated in a RCT for perinatal asphyxia. It decreased the incidence of seizures and free radical production but did not improve the outcomes
Respiratory DistressUse of surfactant replacement therapy ( SRT) was shown to be effective for the first time in India in a large no. of babies.
Chronic Lung Disease was reported as an emerging problem for the first time from India
Editorial Board of Journal of Neonatology ( Bulletin of National Neonatology Forum) 1995-99 , 2005-till present
Advisory Board of Journal of Neonatology ( Bulletin of National Neonatology Forum) 2000-04
Member of Publication Committee of National Neonatology Forum 1999-2003
Member of Equipment Committee of National Neonatology Forum 1999-2003
Convenor of Equipment Committee of National Neonatology Forum 2004-till date
Member of Board of Medical Experts for certifying Brain Stem Death at PGIMER, Chandigarh July2005
Invited in 2005 to review for the McMaster Online Rating of Evidence (MORE) system to help build the next generation of information resources to make it easier and fasterfor physicians to reach evidence-based clinical decisions